|
KMID : 0620920180500010017
|
|
Experimental & Molecular Medicine
2018 Volume.50 No. 1 p.17 ~ p.17
|
|
|
Critical effects of long non-coding RNA on fibrosis diseases
|
|
Zhang Yue
Luo Gang
Zhang Yi
Zhang Mengjie
Zhou Jian
Gao Weiwu
Xuan Xiuyun
Yang Xia
Yang Di
Tian Zhiqiang
Ni Bing
Tang Jun
|
|
|
Abstract
|
|
|
|
The expression or dysfunction of long non-coding RNAs (lncRNAs) is closely related to various hereditary diseases, autoimmune diseases, metabolic diseases and tumors. LncRNAs were also recently recognized as functional regulators of fibrosis, which is a secondary process in many of these diseases and a primary pathology in fibrosis diseases. We review the latest findings on lncRNAs in fibrosis diseases of the liver, myocardium, kidney, lung and peritoneum. We also discuss the potential of disease-related lncRNAs as therapeutic targets for the clinical treatment of human fibrosis diseases.
|
|
|
KEYWORD
|
|
|
Chronic inflammation, Clinical epigenetics
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
    
|